A9251
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A9251
Sigma
Adenosine
≥99%
| Synonym: | 9-β- |
| CAS Number: | 58-61-7 |
| Linear Formula: | C10H13N5O4 |
| Molecular Weight: | 267.24 |
| Beilstein Registry Number: | 93029 |
| EC Number: | 200-389-9 |
| MDL number: | MFCD00005752 |
| PubChem Substance ID: | 24277685 |
Description
| Biochem/physiol Actions | Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD). |
Properties
| assay | ≥99% |
| mp | 234-236 °C(lit.) |
| Gene Information | human ... ADA(100), ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), ERBB2(2064), ERBB4(2066) |
| rat ... Adcy2(81636), Adora1(29290), Adora2a(25369), Adora3(25370) | |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 2 |
| RTECS | AU7175000 |
References
| reference | Hutchinson, S.A., and Scammells, P.J., A1 adenosine receptor agonists: medicinal chemistry and therapeutic potential. Curr. Pharm. Des. 10, 2021-2039, (2004) |
| Fredholm, B.B., et al., Actions of Adenosine at Its Receptors in the CNS: Insights from Knockouts and Drugs. Annu. Rev. Pharmacol. 27, (2004) | |
| Livingston, M., et al., Adenosine, inflammation and asthma--a review. Inflamm. Res. 53, 171-178, (2004) | |
| Sullivan, G.W., Adenosine A2A receptor agonists as anti-inflammatory agents. Curr. Opin. Investig. Drugs 4, 1313-1319, (2003) | |
| Rorke, S., and Holgate, S.T., Targeting adenosine receptors: novel therapeutic targets in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Med. 1, 99-105, (2002) | |
| Merck | Merck 13,154 |
| Beilstein | Beil. 26,IV,3598 |
| FT-IR 1 (2), 720:A / FT-IR 2 (3), 3684:C / FT-NMR 1 (3), 222:A / IR-Spectra (3), 1296:E / IR-Spectra (2), 1128:F / NMR-Reference 2 (2), 597:C / RegBook 1 (2), 2475:K / Sax 6, 138 / Sigma FT-IR 1 (1), 752:C / Structure Index 1, 391:A:6 |
